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It is found that among the prepared samples using a single template, the sample using glucose as template shows the largest area.
Modeling DFG-out structures using a single template may not optimally represent the ensemble of conformations of the N/C-lobes.
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Conversely, we used a single template (2Z7X-B) because it has 19 LRR, which are aligned well with the 19 LRR in the target hTLR10.
Starting from a given protein-ligand complex conformation, two simulations are run that start from different atomic velocities, typically leading to 4 10 protein-bound simulations per ligand when using a single protein template structure.
Their focus, however, has been to maximize the genome's coverage using a single 'best' template, as this is generally sufficient to derive general information about fold and function, as Anand et al.
In our preliminary control screens, it was hypothesized that there may exist distinct binding pocket motifs for an individual compound such that using a single protein template to search for other targets may not identify all true targets of a compound.
In the CUDA version all possible kernel combinations are implemented using a single file with templates.
The LDDMM used in this study enabled us to transform subject images to template images with high accuracy by using a single normalized subject (Johns Hopkins University Montreal Neurological Institute template).
When FC-4 was used as a single template, generally vesicular structures were obtained regardless of the silica sources.
The identities of positive clones were confirmed by PCR using a single colony to provide template DNA.
5' flap sequences (e.g., a 54-mer oligonucleotide rich in G and C bases) attached to the 5' end of a primer is highly efficient during linear PCR (by using a single primer to amplify DNA template in one direction, because there is no partner primer, the amplification is linear rather than exponential).
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