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Importantly, biallelic gene knockout is obtained at high frequency by only one round of targeting using a single marker.
Nevertheless, it has also been suggested that the sensitivity is not entirely desirable in cancer detection by using a single marker [9].
Using a single marker to identify the stem/progenitor population resulted in much more variable counts as CD133+ cell number expanded 10 70 fold (mean 28 fold) and CD34+ cells expanded 8 80 fold (mean 22 fold).
However, it is difficult, using a single marker, to identify a single cell lineage exclusively.
It is unlikely that a molecular discrimination between these diseases can be achieved using a single marker.
In the second stage, these residuals were regressed on ROH4Mb using a single marker regression model and a gradient boosted machine (GBM) algorithm.
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For QTL mapping in the RILs, we used a single marker model, with the percentage of total progeny at a certain stage used as a phenotype.
Seven of the included studies used a single marker to detect CTCs, with the chosen marker being CEA mRNA (n=5), cytokeratin-20 (CK20), or guanylyl cyclase (GCC) (Taniguchi et al, 2000; Ito et al, 2002; Bessa et al, 2003; Chen et al, 2004; Sadahiro et al, 2005, 2007; Koch et al, 2006).
The relationship between the different genotypes of each SNP and the various traits recorded was evaluated using a single-marker mixed-model association analysis.
The power to detect effects is also contingent on the sensitivity of the SNP-MaP approach as well as the coverage of the 500K microarray (66% of common variants captured at r > 0.80 using a single-marker approach; Pe'er et al. 2006), which are two areas likely to improve in time.
The shrinkage factors for HEM are determined on basis of a BLUP estimate of the marker effects u i, whereas RMLA uses a single-marker ANOVA.
More suggestions(15)
uses a single marker
using a single sperm
using a multiple marker
using a nuclear marker
using a single platform
using a single image
using a surrogate marker
using a single antenna
using a single lens
using a single parameter
using a single silicon
using a single hydrophone
using a single nozzle
using a single line
using a single light
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