A world wide directory will allow developers to use a single endpoint regardless of the user's location.
Throughout this paper, we only considered the situation where a single dimension of HRQoL is used at a single endpoint.
This study used a single primary endpoint and non-inferiority margin of 10%, i.e. the trial had adequate power to detect a >10% higher risk of re-bleeding in the group where ASA was resumed immediately.
Formulae corresponding to the commonly used methods in a single endpoint study, which were proposed by [Blackwelder, W.C., 1982. Proving the null hypothesis in clinical trials. Controlled Clinical Trials 3, 345 353] and [Farrington, C.P., Manning, G., 1990.
Conclusion: These observations suggest that technologies which are simple to apply, and have a single endpoint, show concordance between RCT results and clinical use (HUAM, short-term tocolysis, single-course BMZ, TRH, and fFN).
The decrease in Soret band absorbance at 415 nm that occurs when heme interacts with artemisinin was selected as a simple primary readout of a single endpoint assay, rather than using absorption spectra or focusing on the peak that occurs at 476 nm.
One limitation of our study is that it was not possible to use a single definition of follow-up endpoint across the published datasets, in each case we used the most conservative indicator of relapse available (recurrence-free survival, disease-free survival and distant metastasis-free survival) rather than overall survival.
In contrast to tight coupling, a Single-page Application (SPA), which is also sketched in Fig. 2, does not implement any form of presentation-layer integration but only uses a single graphical interface provided by one endpoint together with further interfaces for accessing data from the other endpoints.
Content consumers like Plaxo and MyBloglog benefit from a single endpoint and a standardized way of accessing data.
