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In reality, using a single agent is not practical because of large delay, unbalanced load, and large accumulated size [21, 22].
In recent clinical trials on various human cancers, including melanoma, targeting an individual pathway, such as the MAPK pathway or the PI3K/Akt pathway, or using a single agent generally failed to show significant clinical responses [9], [15], [32].
The number of chemotherapy trials using a single agent alone was 17, while the remainder used more than one agent.
The reviews that admitted such studies into analysis failed on the criterion of using a single agent.
Instead of inhibiting MEK1 using a single agent, our results propose to use it in combination with carboplatin as a sensitizing agent in high grade tumors.
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While 19% used a single agent, 34%, 21%and2.4%4% used 2,3 and more than 3 agents.
Chemotherapy used a single agent in 11.7% of the cases, two in 39.5%, three in 17.8% and four or more in 31.0%.
Third, one can use a single agent to target multiple surface markers that are differentially expressed on cancer cells with progression of the disease.
49 (19.4%) patients used a single agent, while 86 (34%), 52 (21%) and 6 (2.4%) patients used 2, 3 and more than 3 varieties of herbal supplementation to their meals respectively.
Therefore, targeting the Akt/mTOR pathway without enhancing the MAPK pathway seemed to be more preferable than using a single-agent mTOR inhibitor in chemotherapy.
Using a single multitargeted agent, rather than to use multiple single agents, to individually attack multiple targets is an alternative strategy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com