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Using a similar screening approach, Semaphorin-7A was identified as a receptor for the merozoite-specific thrombospondin-related anonymous protein, MTRAP.
Here, we explored the potential for using a similar screening method for the identification of compounds able to induce other trypanosome phenotypes, namely, differentiation between life stages, providing possible tool compounds of value in research, as well as therapeutics exploiting the irreversible proliferation arrest associated with the transition to stumpy forms.
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Mr. Piano used a similar screening system for his 1997 Debis Tower for Daimler-Benz in Berlin, to mixed results.
Based on these findings, a commercial company, now known as Summit plc, used a similar screening mechanism and generated compounds that were developed to the point of out-licencing as anti-tuberculosis leads.
Of the 11 genes that were not tested using promoter fusions, one (AGL61) had been isolated using a similar differential screen and its promoter activity in the female gametophyte had been described previously [ 7, 9].
Using a similar initial glycoarray screening, the existence of (1,3 -β-glucans35 1,3 -β-glucans35 1,3 -β-glucans35 recently shown and validated in brown algal cell walls4.
Using a similar approach, a screen of siRNAs targeting over 5,000 genes in SKOV3 ovarian cancer cells identified five genes including three kinases that potently reduced cell migration [ 6].
Using a similar approach, we screened data for 12,509 Korean individuals and confirmed the participation of 16 known loci associated with hematological traits and also identified one novel genetic locus affecting PLT.
Women in both study arms were invited for screening using a similar letter with general information on screening.
Moreover, the MCD events would be used as a similar screening approach to gene amplifications (multi-copy increases) or homozygous deletions whereby the expectation is that these events would occur at a lower frequency than disruptions through one mechanism alone and observation of these events would signify importance to the genes in question.
In contrast to the previously published screens using a similar reporter element, we adapted the screen to a strictly cell-based analysis using a fully automated high-content imaging and quantitative image analysis platform.
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CEO of Professional Science Editing for Scientists @ prosciediting.com