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Motor function was determined using a rotarod test.
For mice, we measured the latency to fall using a rotarod test to determine whether diet-induced obesity impaired motor function.
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Motor coordination used as a rough estimate of neurological involvement was tested using a Rotarod device (Fig. 4).
The effects of VU0467154 on motor coordination were tested using a rotarod (model 4600, Ugo Basile, Comerio, Italy) with a rod diameter of 3 cm.
Motor coordination and resistance was determined carrying out a specific test designed by using a Rotarod.
Testing of motor function using a Rotarod Treadmill for mice (MK-610A; Muromachi, Tokyo, Japan) was performed once a week.
We followed mice by daily observation for survival and weekly testing of motor-function using a Rotarod device (Panlab, Barcelona) starting at 11 weeks of age.
Effort capacity was measured using a Rotarod (ie by assessing the racing time) and a forced swimming test (a load equal to 5% of the body weight was attached at the base of the tail and the duration of swim was measured).
Motor function was tested between 3 and 14 days after injury by observers unaware of experimental groups using a RotaRod for mice.
We also assessed motor coordination using a Rotarod and found that the ability to stay on the Rotarod decreased significantly with age.
Motor functions were assessed using a rotarod apparatus and a CatWalk gait automatic analyzer.
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