Therefore, in this study we performed the DST using a reduced dose of dexametasone (0.5 mg).
Because of dose-limiting toxicities (Choy et al, 1998; Vokes et al, 2002; Gandara et al, 2003; Zatloukal et al, 2004; Fournel et al, 2005; Bedano et al, 2006; Kiura et al, 2008), these new agents have been tested using a reduced dose or split dose within the newer concurrent chemoradiation regimens.
Finally, unlike the CLOT trial, which used a reduced dose of dalteparin after 1 month, CATCH will use tinzaparin at the full therapeutic dose for 6 months.
Accordingly, the current study used a reduced dose of oxaliplatin (120 mg m−2 every 3 weeks) and chemotherapy was given up to maximum 9 cycles, resulting in that no patient experienced grade 3 neuropathy or discontinuation of treatment and the dose intensity of oxaliplatin was 93.7%.
Canagliflozin is recommended to be used at a reduced dose of 100 mg/day with an eGFR of 45 59 mL/min/1.73 m and is not recommended with an eGFR <45 mL/min/1.73 m.
Other glucose-lowering therapies may be used at a reduced dose but require periodic renal function monitoring prior to and during treatment to avoid inappropriate dosing; for example, insulin, repaglinide and gliclazide require dose reduction in subjects with severe RI 11.
Recent work showed feasibility of performing MBI with either a further reduced dose of 150 MBq Tc-99 m sestamibi or, alternatively, using a reduced acquisition length of 5minperview while keeping administered dose at 300 MBq [7, 13].
Phase 3 treated the primary disease to a total dose of 54 Gy, using a reduced field size (2 cm on gross disease).
Bladder inflammation was produced using a recently published protocol whereby a reduced dose of cyclophosphamide (CYP) is administered to male Sprague-Dawley rats in order to avoid profound weight loss and mortality [6].
Dependent on the dialysis frequency, the dialysis membrane, and the activated partial thromboplastin time, measured before the start of the dialysis session, a reduced dose should be used from the second dialysis.
They also recommend that dosing be resumed at the dose used prior to the event or at a reduced dose at the discretion of the physician.
