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In addition, using a recessive model, we confirm an association between hip osteoarthritis and a variant of CHADL1 (rs117018441, P = 1.8 × 10−25, OR = 5.9).
Some differences were observed in girls using a recessive model.
In DRD2 gene, using a recessive model, we demonstrated that rs1079727 was significantly associated with dyslexia with the allele C as a risk factor after Bonferonni correction.
It might be possible, in principle, to devise some kind of alternative weighting scheme aimed specifically to detect associations using a recessive model.
An additional 4 SNPs reached Bonferroni corrected statistical significance using a dominant model for the top-strand allele, and two SNPs reached Bonferroni corrected statistically significance using a recessive model for the top-strand allele (Table 2).
When we performed similar analyses using a recessive model where the independent between-subject variable was restricted to two genotype categories (s's' vs. s'l'+l'l'), a highly significant genotype effect was also observed (F1, 155 = 11.9, p = 0.0007).
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The main rationale for this was that the previously published Mendelian Randomization study [12] to examine this association used a recessive model and we wished to pool results from that study with those from our new studies.
To test if individuals with the 148M mutations had lower RBP4 protein we chose to use a recessive model.
Based on the previous findings [ 10, 36], we only considered an additive model in testing the associations between these SNPs and adiposity phenotypes except for the SNP near INSIG2 for which we used a recessive model [ 5].
This was not unexpected since rs4961199 was initially identified using a recessive inheritance model [12].
Association analysis of individual SNPs with the 9 years post treatment change in pain and disability scores using a recessive genetic model among 93 patients, revealed statistically significant associations between post treatment improvement in disability (ODI change) and two SNPs from IL18RAP gene, rs1420106 and rs917997 (p = 0.02) (Table 2).
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using a new model
using a prepaid model
using a mechanistic model
using a statistical model
using a single model
using a mathematical model
using a different model
using a computational model
using a similar model
using a replicable model
using a linear model
using a recessive marker
using a logistic model
using a bioeconomic model
using a recessive inheritance
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