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Selection for crossing-over events is possible when using a recessive marker located more closely to the telomere than the other markers, as is the case for cnxD (Debets et al. 1990).
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They obtained a maximum two point lod score of 4.5 at marker D17S1289 (θ=0.07) and a three point lod score of 4.3 using the markers D17S1289 and D17S921 (θ=0.10) using a recessive model.
In addition, using a recessive model, we confirm an association between hip osteoarthritis and a variant of CHADL1 (rs117018441, P = 1.8 × 10−25, OR = 5.9).
This was not unexpected since rs4961199 was initially identified using a recessive inheritance model [12].
Some differences were observed in girls using a recessive model.
This strongly suggests that the haplotype is detecting a recessive marker.
Add designs using a permanent marker.
Outline your moon using a fine marker.
The use of dominant markers allows scoring recombinant progeny in the F2 generation, a generation earlier than mapping schemes using recessive markers, eliminating the need to set up crosses with each recombinant progeny.
QTL mapping using these three recessive markers confirmed the position of a single, large-effect QTL on chromosome 3 at 79.7 to 89.7 cM (2 LOD interval), between wo and ro.
Moreover, standard mapping strategies using recessive markers, although scalable, cannot achieve comparable resolution and often are equally labor-intensive.
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