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This was not unexpected since rs4961199 was initially identified using a recessive inheritance model [12].
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Table 5 shows the relationship between CXCL9-11 polymorphisms and liver stiffness under a recessive inheritance model.
Each was consanguineous and showed a recessive inheritance pattern.
In the GWAS, Fisher's exact test was applied to three genetic models: an allele frequency model, a dominant inheritance model, and a recessive inheritance model.
13 Strisciuglio et al postulated a recessive inheritance in a sibship with a wide variation of expression.
The approach used assumed a recessive mode of inheritance where shared variants could be determined in the affected cases and subsequently filtered out in the unaffected, while maintaining the number of sequencing runs to a minimum.
Multi-point LOD score analysis was performed on each of the families using Genehunter (24), assuming an autosomal recessive inheritance, 100% penetrance and a disease allele frequency of 0.005.
Two-point and multipoint parametric linkage analyses were performed using Superlink (Silberstein et al. 2006) and MERLIN respectively, using a fully penetrant autosomal recessive mode of inheritance with no phenocopies and a disease allele frequency of 0.001.
These data suggested a monogenic recessive inheritance mechanism; therefore, we hypothesized a simple Mendelian recessive inheritance was the most likely explanation for the condition.
We then performed a parametric linkage analysis using a fully penetrant, monogenic autosomal recessive model of inheritance in the family with its 10 informative meioses.
Analysis of a Finnish pedigree of these dogs indicated a primarily recessive inheritance (Jokinen et al., 2007).
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