Sentence examples for using a rationally from inspiring English sources
A new class of Janus kinase (JAK) inhibitors was discovered using a rationally designed pyrrolo[1,2-b]pyridazine-3-carboxamide scaffold.
The PLN were prepared by using a rationally selected composition that was found in our previous work to provide optimized interactions of verapamil hydrochloride (VRP) with dextran sulfate sodium (DS) and then the VRP DS complex with dodecanoic acid (DA).
We describe an efficient yet facile strategy to stabilize Li plating by forming a single Li+-ion solid electrolyte layer in vivo on the Li surface using a rationally designed electrolyte additive.
Here we report the discovery of compounds 6 and 9 using a rationally designed kinase-directed library which potently inhibit Eph receptor tyrosine kinases, particularly EphB2 with cellular EC50s of 40 nM.
A high yielding (50 96%) route to 2-substituted-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid derivatives has been developed using a rationally designed dihydroxyfumarate derivative.
Using a rationally designed mutant of the sialidase from Trypanosoma rangeli, Tr13, with enhanced transsialylation activity, six different GOS preparations with a varying degree of polymerization (DP) were effectively sialylated with molar yields of 20 30% on the CGMP sialyl in batch reactions.
A sulfated tetrapeptide that fits this description and binds to vascular endothelial growth factor (VEGF) was discovered using a rationally-designed combinatorial approach.
In this study we have used a rationally-devised scheme to classify gene and domain architectures of prokaryotic TCS genes and in doing so, identified general features of TCS organisation.
Ideally, it would be possible to ablate endogenous protein function in vivo using an inducible, rationally designed protease selective for a chosen sequence.
Seven phenylalanine derivatives with small ortho substitutions were genetically encoded in Escherichia coli and mammalian cells at an amber codon using a previously reported, rationally designed pyrrolysyl-tRNA synthetase mutant (PylRS N346A/C348A)) coupled with tRNACUAPyl.
In this work, a series of N, S co-doped porous carbons (NSCs) with excellent ORR performance were prepared by rationally using a dual-ligand metal organic framework as a carbon precursor.
