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Here, we extend the optogenetic toolset by developing a neuromodulatory approach using a rationale-based design to generate a Gi-coupled, optically sensitive, mu-opioid-like receptor, which we term opto-MOR.
Starting from the canonical structure of these models (schematic diagram in Figure 1a ), we reduced the signaling network using a rationale-based approach to obtain a more parsimonious description while retaining the essential features of the IL-6 signaling pathway.
By using a rationale-based strategy and a reverse target-identification approach (identifying the target(s) of a compound after unveiling its cellular phenotype or biological activity), we excavated a likely mechanism that attributes to the activation of p53 by this compound, that is inhibition of SIRT1 activity (Fig 8).
These results provide an experimental basis to interpret the failure of PE treatments and to propose a rationale, based on the use of DHPs, for a potential approach in the management of the pathology.
SK Telecom defended the purchase using a rationale that left some corporate critics even more perplexed.
This European Space Agency "Part Standard Specification-01-301" (Derandng and End of Life performance prediction document) is being up-dated using consistent rationales based on recognized acceleration laws and Ea, and physical models.
The present paper offers an alternative rationale, based on a fixed-factor neoclassical model with traded and non-traded goods.
He has done his homework and presented a compelling rationale based on fact and precedent.
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