They used a rat preparation, which allows for the preservation of much longer sensory afferents for enhanced temporal separation between A- and C-fiber input than is generally possible with mice, resulting in reduced response noise.
First described by Tune and Coyle [ 23], SAA measures the ability of a individual's serum to block central muscarinic receptors using a rat forebrain preparation.
We used a rat kidney transplantation model with strict transplant and sample preparation procedures to analyze genome wide changes in gene expression four days after syngeneic and allogeneic transplantation.
Similar results were obtained using a commercial preparation of rat tail collagen.
Therefore, in this study, we investigated the NPY modulatory effects at RGC level using a purified rat RGC culture and an ex vivo rat retinal preparation.
Using a real rat, though, House confronted Chase as the real rat.
Compound 23g showed a high level of Rho kinase inhibitory activity in the rat serum and was stable in an in vitro metabolic test using a microsomal cytochrome preparation.
More importantly, by making transgenic rats instead of transgenic mice, we can avoid the argument of species difference [23], [24] and make our measurements more directly comparable to the results using rat preparations.
In the previous issue of Critical Care, Zausig and colleagues examined the direct effects of intravenous anaesthetic agents on the myocardium, using an isolated septic rat heart preparation [ 1].
A cumulative concentration response curve (CRC) for acetylcholine (Ach) and histamine (1 256 μM) was recorded on a 4-minute time cycle (a 30-second base line, followed by 30 sec of contact time and three subsequent washings at 1-minute interval) using isolated rat ileum preparation.
