More recently, using a quantitative analysis of inclusion pathology, Schuldi et al. reported that inclusions of poly GA) are less frequent in cerebellar granule cells of patients with ALS (n = 3) and FTLD-MND (n = 8) compared to patients with FTLD (n = 3) [ 30].
Total hCG β levels in serum samples were determined by an accredited UK National Health Service chemical pathology department using a quantitative chemiluminescent immunoassay on a Beckman Coulter DxI immunoassay system (product number 33500, Beckman Coulter, High Wycombe, UK).
Even with the limited number of samples, a previously associated AD gene (DHCR24) and an intronic SNP (rs7551288) within this gene were identified in the present analysis, highlighting the potential of using a quantitative imaging phenotype to identify gene regions that may be associated with disease pathology.
These findings were possible only by using a quantitative methodology as semi-quantitative assessment shows 'severe' nigral cell loss and 'severe' amounts of hyperphosphorylated tau, Aβ, and α-synuclein pathology in most cases, making it impossible to detect any differences with regard to the amount of pathology in this study cohort.
Postulating that the density of LN was a more relevant marker than their mere presence/absence, we used a quantitative Lewy pathology score.
Our prototype represents the first step on the path towards a quantitative pathology.
For this purpose, we used a quantitative measure of HWD.
Here, we use a quantitative immunoassay of aggrecan ARGS neoepitope fragments in human synovial fluid to determine if this cleavage-site specific method better identifies joint pathology than previously available less specific aggrecan assays.
He is also the co-Lead of the substudy to look for phenotypic evidence using Quantitative Pathology in margins for surgical field shift.
The literature review also demonstrated that cartilage pathology can be measured reliably and with good responsiveness by using a semi-quantitative or quantitative technique [ 26].
