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These data from population-based studies or randomized trials will need additional validation using a prospective trial before implementation.
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Cost-effectiveness will be estimated using a prospective within trial analysis of treatment effects analysed on an intention-to-treat basis and a decision model of long-term costs and health outcomes.
The effectiveness of the intervention program will be evaluated using a prospective controlled trial design in which schools will be matched, with a follow-up of one school year.
Attempts to provide answers showing a preference for one surgical technique over another using a prospective randomized clinical trial would be difficult in the face of such a wide spectrum of factors.
We carried out pilot testing of this hypothesis using a prospective, single blind, randomized controlled trial.
We carried out pilot testing of this hypothesis using a prospective, single blind, randomized control trial.
Shegog et al [ 12] showed significant improvement in knowledge and asthma self-management using a prospective pretest-posttest randomized intervention trial.
The kContact intervention developed in the first stage of this study will be trialled using a prospective design that compares (i) children and young people who receive treatment as usual (standard contact) with (ii) children and young people receiving the kContact intervention, at baseline and nine months.
In this case control study, using samples from a prospective trial, we describe differences in multiple pleiotropic serum inflammatory factors in post-menopausal women who develop this toxicity compared with those who remain asymptomatic.
A prospective trial using 6% HES 200/0.62 demonstrated a detrimental effect on initial graft function [ 12].
Validation is required in a prospective trial using a large number of patients following which response is likely to be based exclusively on PET criteria.
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