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There are various concurrent chemotherapy combinations that have been trialed, with most using a platinum compound as a backbone.
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A novel analytical system was developed to rapidly and accurately quantify total volatile organic compound (VOC) production from microbial reactor systems using a platinum catalyst and a sensitive CO2 detector.
It has been shown that the use of a platinum compound decreases CTR1 expression [ 12] and causes secondary platinum resistance [ 35].
In East Asia, including Japan and Korea, a fluoropyrimidine plus a platinum compound has been used as standard therapy (Koizumi et al, 2008; Kang et al, 2009).
IDEAL 2 recruited 216 patients in the USA, who had previously received ⩾2 chemotherapy regimens, including a platinum compound and docetaxel, used either together or as separate regimens (Kris et al, 2003).
At present, the most widely used treatment consists of a fluoropyrimidine and a platinum compound.
The findings of our original meta-analyses, as well as the trends observed on our adjusted indirect comparisons support the use of gemcitabine in combination with either capecitabine or a platinum compound in clinical practice.
Oxaliplatin is a platinum compound that is increasingly being used for the treatment of colon cancer.
The advent of irinotecan has brought new opportunities for the management of metastatic gastric cancer by enabling use of combinations that do not contain a platinum compound such as oxaliplatin or cisplatin.
In Western countries, regimens containing a fluoropyrimidine (fluorouracil or an oral preparation) plus a platinum compound, and usually including docetaxel or epirubicin, have been most widely used.
Using the adjusted indirect comparison method proposed by Bucher et al, we have assessed randomised controlled trials of four gemcitabine based combinations namely gemcitabine plus a platinum compound or 5-fluorouracil or irinotecan or capecitabine.
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