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The pfp is calculated using a permutation based procedure (100,000 permutations were conducted).
We identified 740 probesets (640 genes) and 331 probesets (282 genes) using a permutation based FDR of 8.2%, and BH FDR of 5% respectively, as being differentially expressed between the two strains of mice.
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In order to establish accurate empiric P-values we used a permutation based, topology-corrected method.
Three traits of tassel and ear architecture were evaluated in this population, a total of 10 QTL were detected using a permutation-based-significance threshold, seven of which overlapped with reported QTL.
Systems biology studies produce variables with wide continuous ranges, and thus we are less likely to encounter bias when using a permutation-based variable importance measure.
Additionally, an empirical p-value was determined using a permutation-based method robust against non-normality of the underlying distribution [32].
Using a permutation-based method; SAM calculates an expected score for each gene, representing the random fluctuation in gene expression when there is no real significant difference in gene expression.
Clusters of genes anti-correlated to miR-210 expression were formed as described previously [25]; Spearman correlation was used to identify genes significantly anti-correlated miR-210 and false discovery rate (FDR) was estimated using a permutation-based method [42].
The significance of PEM scores was assessed using a permutation-based procedure.
The relationship between gene expression and microRNA expression was measured by using a permutation-based correlation method.
The significance of the overexpression of gene set S in cell type l was measured using a permutation-based approach.
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