We next addressed whether cleaved amyloid β peptides localize similarly to APP using a peptide-specific antibody.
Previously published peptide transport assays tend to follow peptide uptake using a radiolabeled peptide substrate.
Remarkably, pharmacological complement blockade using a C5a peptide antagonist was equally effective at limiting tumor growth as the conventional chemotherapeutic drug paclitaxel.
Specific NF-κB blockade using a small peptide inhibitor of IKK-β has anti-inflammatory effects in AA and human RA synovial tissue as well as in two important cell types in the pathogenesis of RA: macrophages and FLS.
Our data indicate that local IKK-β-targeted NF-κB blockade using a small peptide inhibitor ameliorates synovial inflammation, both in an animal model of arthritis and in human RA synovial tissue ex vivo, which opens up a new approach for the local treatment of RA.
Non-NMDA receptor-mediated synaptic responses were isolated using a pharmacological blockade of NMDA and GABAA receptors.
Using a neuromuscular blockade monitor add muscle relaxants as needed.
These antibodies were generated in sheep using a nested peptide series conjugated to the metalloprotein, KLH.
Characterization of antibodies against histone PTMs used in the study was performed using a Histone Peptide Array (Active Motif, 13005).
Characterization of prorenin activation using a synthetic peptide substrate.
