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C. Explore gene-gene interactions using a novel gene-based statistical approach.
This will involve: conducting conditional tests to identify the causal genetic variant among multiple correlated signals; testing whether the effect of PTSD genetic risk variants is moderated by age of first trauma, trauma type, and trauma severity; and exploring gene-gene interactions using a novel gene-based statistical approach.
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Utilizing a novel gene-based (statistical) approach, we aimed to identify specific genes and pathways associated with both MA and MO.
GAP calculates functional relatedness among all 19,027 human protein-coding genes using a novel taxonomy-based semantic similarity measure (as described below).
Today Kirik, a neuroscience professor at Lund University in Sweden and co-founder of a spinoff company, uses his medical background to develop novel gene-based therapies for Parkinson's disease and bring them to the clinic.
GAP integrates different biological features using a novel taxonomy-based semantic similarity measure in predicting and prioritizing high-quality putative gene associations.
TRFLP data from all samples were aligned and analyzed using a novel frequency-based alignment method to avoid the errors associated with integer-based fragment length "binning" [28].
A strategy for activity-based enzyme detection using a novel enamide-based chemical strategy is described.
To develop a reproducible and accurate method of gene expression analysis on synovial biopsies, we evaluated and validated real-time quantitative PCR (Q-PCR) on very small synovial tissue samples using a novel cell-based standard curve technique.
Structural characteristics of a set of dihydropyridine derivatives were studied using a novel group-based QSAR analysis.
Newly synthesized type II collagen was quantified as a marker of cartilage formation using a novel ELISA-based system [ 26].
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