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Based on Forchheimer equation and taking 10% of the nonlinear effect as the critical state to distinguish between linear and nonlinear flow, the critical Reynolds number was successfully estimated by using a nonlinear effect coefficient E. This method appears effective to determine critical Reynolds numbers for specific flow cases.
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The IC50 was estimated by using a nonlinear mixed effect model.
PBPK brain distribution modeling was performed to investigate the effect of time of administration on the pharmacokinetics of quinidine in plasma, total brain, ECF, and CSF quantitatively using a nonlinear mixed effect model approach with NONMEM software version VII (GloboMax LLC, Hanover, MD, USA).
A population pharmacokinetic approach using a nonlinear mixed-effect model was implemented [ 1].
Population pharmacokinetics analysis was performed using a nonlinear mixed-effect modeling approach with NONMEM software (ICON Development Solutions, Ellicott City, MD).
Using a nonlinear mixed effects population model, individual estimates of pharmacokinetic parameters were derived and used to estimate imatinib exposure (area under the curve, AUC) in 58 patients.
LOD and LOQ were calculated using a nonlinear mixed effects model with log-linear variance function from the 17-point serial dilution series.
We have shown that VFM trajectories of the normative population and individual subjects can be characterized and predicted by modeling for the nonlinear growth patterns using a nonlinear mixed effects framework.
All the simulations are conducted using a nonlinear power system model, and the effect of the nonlinear factors of the system is incorporated in the simulation data.
Using large observational study in Northeast China, Temesgen et al. (2014) used a nonlinear mixed effect model with species indicators to make tree height predictions compatible and precise for 23 tree species found in multi-layered forests in NE China.
Population PK analysis was conducted using nonlinear effect modelling to derive PK parameters [30].
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