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These artefacts can be avoided by using a negative contrast agent.
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These nanosystems were used as a negative contrast agent for MRI in a nonclinical study to visualize, in a rat model of liver ischemia, ischemia reperfusion injuries.
Trans-abdominal US of the bowel has developed as a technique, and oral solution can be used as a negative contrast agent within the bowel to examine the lumen for evidence of filling defects or complications of inflammatory bowel disease, whilst simultaneous intravenous UCA can allow assessment of the bowel wall [24, 25].
The MEME analysis parameters used by Yang et. al., differed from ours in two key aspects: 1) a maximum motif width of 20 (instead of 30) was specified; 2) discriminative motif discovery was performed using a negative set of "background" sequences contrasted against a set of target sequences extracted from the top 148 peaks in their ChIP-seq dataset.
Some centres use a negative oral contrast agent (e.g. iron oxide or blueberry juice) to reduce the signal intensity of overlapping fluid within the stomach and duodenum, although this is not part of our routine protocol.
In neonate children, the concurrent use of air during CT has been a valuable aid in the diagnosis of TEF, serving as a negative contrast medium [ 21, 22].
By contrast, when a lower cut-point was used a negative test excluded TB.
You should not use a negative approach.
Using the negative contrast imaging technique, it was possible to use CLI to image the blood vessels in nude mice due to the high absorption of red and infrared light by the red blood cells compared to the surrounding tissue [19].
In this paper, we evaluate a new approach to CLI using negative contrast imaging to image the light attenuated by the blood vessels.
While blood vessel imaging using negative contrast CLI could possibly be performed with other radiotracers, [68Ga]GaCl3 was optimal for blood vessel imaging for a few reasons.
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