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After DNA alteration, the student can determine the type of phenotype change caused by the mutation using a "mutation table".
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Non-protein-coding variants with reported phenotypic impacts were obtained from the Human Gene Mutation Database HGMD Professionall version, release December 2013), using the mutation table PROM, which contains substitutions that cause regulatory abnormalities [ 33].
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The model was validated experimentally using an ANOVA table.
Relatively smaller numbers (n = 145) of clusters were identified using frameshift coding mutations (Table S3B) because only 1,634 of the transcripts show frameshift coding mutations in at least one strain compared to the BN reference genome.
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In addition, prior probabilities of carrying a BRCA1 or BRCA2 mutation were determined for each patient using mutation prevalence tables and the Penn II mutation prediction model [ 35- 37].
As described above, the E710A and Y766A mutators are impaired in the processing of at least a subset of correct base pairs, making the early checkpoints less effective in screening out mispairs so that a higher frequency of these errors can be recovered as mutations using an appropriate indicator gene (Table 6).
4 ASCO criteria and/or prior probability of a BRCA mutation ≥ 30% using Myriad mutation prevalence tables and the Penn II mutation prediction model.
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