Sentence examples for using a mouse line from inspiring English sources
We expressed an activated form of β-catenin in subsets of chondrocytes using a mouse line with the exon 3 of β-catenin floxed (CatnbEx3) [24].
We then describe an in vivo gain-of-function genetic experiment using a mouse line carrying a functional Map3k4 bacterial artificial chromosome (BAC) transgene.
We addressed these mechanistically important questions using a mouse line that allows inducible Schwann cell-specific Frabin/Fgd4 deletion in adult animals.
The model was generated through Cre-LoxP in vivo recombination (Brault et al., 2006) using a mouse line carrying two loxP sites inserted at App and Runx1 in a cis configuration, as described previously (Raveau et al., 2012).
To further validate our observations, we conditionally deleted merlin in the neuronal cell compartment using a mouse line that expresses Cre recombinase under the neuron-specific promoter Nefh (Nefh-Cre Nf2flox). Nefh-Cre Nf2flox
The new data confirm the important finding previously obtained from the same group (using a mouse line Tg for a CD1b-autoreactive human TCR), that CD1b-expressing hematopoietic cells are the main drivers of thymic positive selection.
We turned to commercially available transgenic mouse tools to determine if we could use a mouse line containing a GFAP promoter to drive expression in peripheral non-myelinating Schwann cells.
To test this idea, we used a mouse line in which a single Pcdhg isoform (PcdhgC3) can be expressed in any cell type in a Cre-dependent manner (Lefebvre et al., 2012).
We have used a mouse line transgenic for human P301S tau protein [17] that exhibits the essential features of human tauopathies to study the usefulness of the Congo red derivative FSB for detecting filamentous tau inclusions.
To alter neurotrophin expression by supporting cells, we used a mouse line that expresses the tamoxifen-inducible Cre recombinase (CreERT) under the control of the proteolipid protein 1 promoter (Plp1/CreER T ).
The technique for developing monoclonal antibodies was developed by Drs. Georges Kohler and Cesar Milstein, using a mouse tumor line developed by NIH.
