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Using a more lenient criterion (e.g., 0.02 or 0.01) increases precision but at the cost of some upward bias in the estimates that is not modeled here.
To test our hypothesis that stimulants increase basal ganglia activation, which is more difficult to detect in fMRI due to their relatively small size, we explored the data using a more lenient p <.05.
Of particular relevance to clinicians and researchers, separate analyses of studies using a cut-off most consistent with major depression and previously validated against clinical criteria (CED-D>20) 57 demonstrated somewhat higher risk estimates (dementia HR 1.83 (trend) and AD HR 1.97) than those using a more lenient cut-off (CES-D>16; dementia HR 1.58 (trend) and AD HR 1.69).
Using a more lenient quality standard for the less polymorphic class II genes (90% of the regions with coverage of 20-fold), of all the 370 alleles (47% of all the tested alleles), only one HLA-DRB1 allele was ambiguous at the four-digit resolution, while the other 369 alleles were correctly typed.
Multiple complete apicomplexan genomes (Heiges et al., 2006; Gajria et al., 2008; Aurrecoechea et al., 2009) were also searched for LDH and MDH homologs in order to fill out the apicomplexan portion of the tree (using a more lenient significance cutoff of E-values <10−4).
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The Denver Broncos used a more lenient definition: Elway got credit for leading a comeback if the Broncos were tied in the fourth quarter.
This figure doesn't change significantly if we use a more lenient cut off of e < 10-2, weere we hit 24,093 (79%) and 30,719 (67%), respectively.
GFI and AGFI values greater than.95 indicate good model fit (Kline 2005); although others use a more lenient cut-off of.90 or even.85 (see Schniering and Rapee 2004).
We note that in two of our four experiments, visual perceptual load also led to a change in response criterion: High perceptual load led participants to use a more lenient response criterion, resulting in a greater rate of false alarms.
Therefore, we used a more lenient P-value threshold for prioritization and annotation of a set of 'promising' SNPs, reported estimates of variance explained by all GWAS SNPs and made available the complete set of our GWAS results.
Therefore, we also used a more lenient definition, 'mild HE', defined as the presence of at least one of the following symptoms or combinations: redness and itch, redness and scaling, itch and scaling, fissures and redness, fissures and itch, fissures and scaling, vesicles, or papules, all irrespective of duration or recurrence.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com