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Three previous studies have shown efficacy using a modified release preparation of soy lecithin containing 30% PC (18, 19, 20).
Therefore, the most advanced approach to optimize the risk-benefit ratio of long-term low-dose GC treatment is the GC-chronotherapy, using a modified release (MR) prednisone (release during the night) and following the circadian rhythms.
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More recently, a modified release tablet of prednisone was developed, releasing prednisone about 4 hours after ingestion.
Its absorption was very rapid though, which led to efforts to develop a modified release formulation.
Additional molecular modeling was performed using a modified version of a more recently released template of a tandem pore potassium channel with a different amino acid backbone connectivity.
Transmitter release was computed using a modified version of a previously described sensor model (Lou et al., 2005 ).
The amount of inorganic phosphate (Pi) released was quantified using a modified malachite-green method.
Liposome release assays were performed using a modified version of that described previously.
All ligand-based VS experiments were performed using a modified version of the Directory of Useful Decoys (DUD) Release 2 [53] 53].
In vitro release studies and drug permeation studies through ASC were carried out using a modified Franz diffusion cell.
The release of ADP in 65 % hydroethanolic solution was carried out using a modified diffusion cell according to the method adopted by Deo et al. [12].
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