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Patients will be randomised using a minimisation programme called Minim [ 8].
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A central randomisation system using a minimisation algorithm provided each child with a unique treatment number.
Randomisation was done centrally at the EORTC headquarters, Belgium, using a minimisation technique.
Randomisation was stratified by study site and baseline DAS28 ESR (≤ or >5.5) using a minimisation algorithm.
Eligible patients will be randomised to the intervention or control strategies using a minimisation approach.
We allocated practices using a minimisation algorithm, and did analyses by intention to treat.
Patients were randomised 1 : 1 between the study arms, using a minimisation algorithm incorporating a random component (Scott et al, 2002).
Then they were randomised after stratification by PS (0 1 vs 2) and by institution using a minimisation process with a probability of 0.75 (Pocock, 1985).
Eligible patients were randomised at baseline using a minimisation algorithm that was stratified by site and baseline DAS28 based on erythrocyte sedimentation rate (ESR) (≤ or >5.5).
Randomisation was achieved using a minimisation method to balance treatments over two stratification factors: study site and AVF location (upper versus lower arm).
Randomisation was performed using a minimisation technique (Pocock and Simon, 1975), stratifying patients by centre, prior adjuvant chemotherapy (yes or not) and ECOG performance status (0 1 vs 2).
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