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The in vivo characteristics of the preparations were determined in BALB/c nude mice, and PET images were acquired 1 h p.i. using a microPET scanner.
When using a microPET scanner with a long axial-FOV, such as Inveon for small animals, the main scatter source is located inside the FOV.
Briefly, imaging data were acquired in animals anesthetized with isoflurane (2% to 2.5%) (Piramal Critical Care, Orchard Park, NY, USA) using a microPET scanner Focus-220 (Siemens AG, Malvern, PA, USA).
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In contrast to other authors, we used a microPET scanner that was suitable for small animals instead of a normal PET scanner for patients (Koort et al. 2004, Jones-Jackson et al. 2005, Makinen et al. 2005a, Lankinen et al. 2012).
In vivo PET investigations were performed using a microPET Focus 120 scanner (CTI Concorde Microsystems, Knoxville, TN, USA).
PET imaging was performed using a microPET Focus 120 scanner (CTI Concorde Microsystems, Knoxville, TN, USA).
Four out of 11 studied animals underwent a dynamic 60-min small animal PET scan using a microPET Focus 220 scanner (Siemens Medical Solutions, Knoxville, TN, USA).
The data was acquired using a microPET R4 rodent model scanner (Siemens Medical Solutions, USA) with a field of view (FOV) centered on the brain region of each rat.
Molecular imaging was performed using a microPET R4 rodent model scanner (Concorde Microsystems, Knoxville, TN).
Small animal PET of tumor-bearing mice (n = 3 each group) was performed using a microPET R4 rodent-model scanner (Siemens Medical Solutions USA, Knoxville, TN).
PET scanning was performed using a microPET II small-animal scanner [ 15, 16], a system that reconstructs images with a spatial resolution of approximately 1.2 mm using conventional analytic reconstruction algorithms.
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