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Because of this, pulmonary targeting, such as inhaled delivery, is believed to provide an advantage over systemically administered compound (IV or oral) because the same degree of efficacy may be achieved using a lower dose of inhaled drug.
Within a few years, however, doctors realized that using a lower dose of mifepristone and a higher dose of misoprostol produced better outcomes for their patients.
Similar range of inhibition was measured using a lower dose of chloroquine (10 µM) (data not shown).
To address this concern, we performed a second in vivo trial using a lower dose of inoculation (1×107 CFU).
To further address this possibility, we directly compared swi3Δ and rad3Δ cells in the recovery of broken forks, using a lower dose of CPT and longer recovery time points (Figure 5C).
Using a lower dose of photosensitiser markedly reduced damage.
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Based on previous research [16], we hypothesized that a formulation using a lower doses of sumatriptan may improve safety and tolerability while maintaining efficacy similar to 6 mg SC sumatriptan, and that a 3-mg dose may be sufficient in many patients.
Moreover, this year at Kendal Calling, four in 10 reported that they now intended to use a lower dose after using the service.
When the drug is used to control bleeding in or around the brain, as in patients suffering from hemorrhagic stroke, one out of 17 patients would get a dangerous clot at the higher dose that is often used and one out of 33 would get a clot in situations where doctors used a lower dose.
In the case of Rat-1, we used a lower dose of blebbistatin (15 µM), which also destroyed actin bundles and stopped the assembly of radial AJs.
For the next series of experiments we used a lower dose of 10×106 RC rather than a dose of 50×106 RC or higher that is typically used in mortality studies in animals not treated with immunosuppressive agents [35].
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