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This method first estimates the generation time distribution using a likelihood based method.
This is a standard approach in the context of meta-analysis [ 10] and by using a likelihood based approach we can easily fit models with the flexible variance structure we require.
For example, purifying selection on synonymous sites was found in 9.4% of all yeast genes and 5.1% in all worm genes using a likelihood based model that distinguishes between synonymous substitutions between preferred and unpreferred codons [ 12].
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We used a likelihood based approach to determine evolutionary relationships of the N. vectensis NRs with bilaterian NRs.
The primary efficacy analysis will assess average treatment group differences for the primary outcome measure (MADRS) over the entire study period and use a likelihood based mixed-effects model, repeated measures (MMRM) approach at each time point.
The age of the most recent common ancestor of mutation carriers was estimated using a likelihood-based method with the ESTIAGE program, based on the length of the haplotype shared on each side of the disease locus (Genin et al., 2004).
Thus, sound-sound link weights should be determined using a likelihood-based technique.
A statistical analysis of injury trends was conducted using a likelihood-based negative binomial time-series method for count data where the rate of injury can depend on past rates, past observations and covariate values.
Data from the Healthy Community Study will be analyzed using both cross-sectional and longitudinal models that account for the complex design and correct for measurement error and bias using a likelihood-based Markov-chain Monte Carlo methodology.
Using a likelihood-based method and a nonparametric method, we estimate the serial interval and reproductive number throughout the course of each outbreak.
The test for positive selection was conducted using a likelihood-based method, where the likelihood of different evolutionary models is computed given a gene sequence alignment and a reconstruction of the phylogenetic history of the genes.
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