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To summarize, using a large series of phantom experiments, we investigated the following four questions: 1.
The validity of the premixed flamelet equations and the dependence of the fuel burning rate on the parameters involved in these equations have been investigated using a large series of direct numerical simulations of turbulent premixed flames in the thin reaction zones (TRZ) and the distributed reaction zones (DRZ) regimes.
As a matter of fact, only training and validation using a large series of histological samples would be able to give more objective and detailed results.
The updated version of BOADICEA was one of the models used in a recent validation study of BRCA1 and BRCA2 carrier prediction algorithms (Antoniou et al, in press a) using a large series of families seen in the UK genetics clinics.
This is the first study that evaluates Bmi-1 in plasma by using a large series of primary breast carcinomas to investigate the presence at diagnosis of detectable Bmi-1 mRNA in plasma and possible correlations between this event and a series of clinical-pathological parameters of the tumors.
Jones et al., using a large series of patients (#256) undergoing TKA, reported pre-operatively average pain score of 43, increasing to 75 six months after surgery (100 indicating no pain); the study did not report the use of NSAIDs [ 31]. Baker et al. reported that 19% of patients still suffered persistent pain one year after TKA [ 32].
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Additional studies using a larger series could clarify the actual impact of clonality on clinical outcomes.
None of the papers addressed the crucial aspect of applicability and reproducibility when using a larger series of independent devices.
Further investigation may be required using a larger series of samples to determine the association between gender and BE.
Moreover, by using a larger series of families screened for CDH1 point mutations and rearrangements, in five reference centers world-wide and arising in countries with different GC incidence rates, we aimed at clarifying the frequency of CDH1 germline alterations and its relationship with GC incidence as well as with clinical criteria for selection of patients at risk.
The idea is to use a large series A round to accelerate the startup to almost Google-like recognition levels in about two years – no small feat.
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