In the future, by using a larger control group, we will be able to provide age- and gender-dependent values for the WR.
No further significant improvement was observed using a larger control group (>50 controls), therefore, we restricted our maximum number of controls to 50.
Inevitably, the cases in this study are also few, but to increase the power of the study we used a larger control group of 309 individuals, giving 90% power to detect an OR⩾1.5 for carriers of at least one C allele, which is enough power to detect the increased risk of 2.1 reported by Young et al (1999).
To conclude; using a large case control material and simple, straightforward statistical analysis we have shown that HLA-A confers an additional influence on MS susceptibility in the Swedish population, not attributable to the known HLA-DRB1 association.
This study is unique in that it directly compared strategies individually and in combination using a large, prospective, controlled design.
Using a large bank of control sera, Raoult et al. (1 ) estimated that a Bartonella IgG titer >1,600 has a positive predictive value for endocarditis of 0.884.
That is, when using a robust methodological work (i.e., using a large sample and controlling for covariates and type I errors), personality-health associations found in the general population are replicated in pain settings.
However, a parallel groups design (randomising participants to complete either the written or the Internet version) would offer a valuable complement, in that using a large, representative sample would control for both known and unknown confounders and eliminate the possible bias due to memory.
Six autoimmune associated variants and a single functional variant were genotyped using a large Australian-based case-control study of prostate cancer.
We sought to replicate specific findings of association between GRM3 and schizophrenia in European and European-American samples using a large, UK based case-control sample.
