Sentence examples for using a large animal from inspiring English sources

Using a large animal DBS model, this study was designed to explore the network effects of CM-Pf DBS.

The feasibility and safety of a sustained, continuous drug-releasing cervical polymeric implant for use in clinical trials was studied using a large animal model.

Interestingly, some research has progressed to the stage of preclinical studies using a large animal model and clinical study, and we introduce such recent scaffold-free approaches with high potential clinical impact.

To investigate the impact of prenatal T excess on the expression of key ovarian regulators implicated in follicular recruitment and persistence using a large animal model of polycystic ovarian syndrome (PCOS).

It is also necessary to evaluate the customized scaffolds using a large animal model with a normal immune system to confirm their regenerative performance in vivo.

Thus, before moving from pre-clinical into clinical studies, it may be prudent to validate and extend the recent experimental findings by carrying out additional studies, using a large animal model of pneumonia.

Previously, the effect of PTH on rabbits has only been investigated using intact bone (Hirano et al. 1999, Mashiba et al. 2001), whereas no previous studies have evaluated the effects of PTH on distraction osteogenesis using a larger animal such as the rabbit.

That study was performed in rats, which have limited intracortical remodeling; it was therefore of interest to investigate the effects of PTH on distraction osteogenesis using a larger animal model with a cortical bone remodeling pattern more similar to that of human cortical bone.

Notably, we used a large animal model that closely reflects hemodynamic changes seen in septic patients with a hyperdynamic circulation [ 18, 19].

In addition, this model would give us the opportunity to use a larger animal with more substantial tissue mass than in the rat model.

The importance of comparative studies using a large range of animal models was highlighted by Sanchez Alvarado and Tsonis [ 4] who described the differences and similarities in the regeneration mechanisms among diverse animal species.