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We performed our analysis using a hypothetical cohort of HIV-positive patients presenting to municipal health clinics with symptoms of pulmonary TB (e.g., cough of three weeks' duration).
Third, the base case analysis was performed using a hypothetical cohort.
Each of these estimates carries inherent uncertainty, as does using a hypothetical cohort.
We developed a Markov decision model using a hypothetical cohort of patients to compare annual breast cancer screening over 25 years with either breast MRI or mammography among young women with ≥ 15% cumulative lifetime risk of breast cancer according to the Claus tables.
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We use a hypothetical cohort of 100,000 pregnancies as the study model.
The model base case used a hypothetical cohort comprising of 1000 surgeries in the first year and followed a 5.2%% annual increase each year.
Three studies used a hypothetical cohort [ 34, 39, 58] and three studies did not clearly specify their sample size [ 30, 38, 52].
In contrast, a study in Brazil [ 16] used a hypothetical cohort including all the Brazilian citizens with Type 2 diabetes and estimated a total annual cost of hospital admissions per patient starting from US$2,151.
For example, Saito et al 58 used a hypothetical cohort of 25-year-old men weighting 60 kg followed for 1 year, while Blackhouse et al 61 assumed a cohort of those aged 37 years weighing 73 kg and being followed for a period of 5 years.
For the base-case analysis we used a hypothetical population cohort of patients with the starting age of 65 years with NVAF who were at increased risk for stroke (CHADS2-score >1) with no contraindications to anticoagulation as reported in the ENGAGE study [ 1].
The total burden of 100% (single) use of rosuvastatin in a hypothetical cohort of 100 patients was €1.07 million versus €1.13 million for atorvastatin, €1.17 million for simvastatin, and €1.19 million for pravastatin.
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