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This means that the risk-benefit is less heavily weighted in favour of using a highly efficacious but potentially teratogenic drug than is the case in parasitologically proven cases.
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We have preliminary addressed how mitophagy might play a role in the regulation of induced pluripotency using mdivi-1 (for mitochondrial division inhibitor), a highly efficacious small molecule that selectively inhibits the self-assembly of DRP1, a member of the dynamin family of large GTPases that mediates mitochondrial fission.
We recently addressed whether mitophagy might play a role in the regulation of induced pluripotency using mdivi-1 (for mitochondrial division inhibitor), a highly efficacious small molecule that selectively inhibits the self-assembly of DRP1 [ 31- 33], a member of the dynamin family of large GTPases that mediates mitochondrial fission [ 34- 36].
A reasonable sample size was estimated to be 40 50 patients per group, if a highly efficacious drug was used.
Etorphine is a highly efficacious and potent opioid that has been used to immobilize large animals such as elephants (Jainudeen, 1970).
Although a small number of patients could be included in this trial, our findings support those of earlier studies demonstrating that PEG spray is a highly efficacious site specific barrier for laparoscopic use.
Evidence supports the feasibility of developing a highly efficacious malaria vaccine.
Ureteroscopy has been shown to be a highly efficacious and safe modality for the treatment of pediatric urolithiasis.
Over one-third (34.6%) reported intentions to increase post-vaccination risk behaviors in response to a highly efficacious HIV vaccine.
Targeting PD-L1/PD-1 signaling has been shown to be a highly efficacious cancer immunotherapy (Brahmer et al., 2012; Topalian et al., 2012).
In summary the data presented outline the pre-clinical development of a highly efficacious, tolerable and safe non-replicating vaccine delivery strategy.
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