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Temporal features were automatically extracted using a heuristic searching for peaks in the point-biserial correlation coefficient between targets and nontargets.
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Parsimony analyses were conducted using a heuristic search strategy.
Optimum designs are generated using a heuristic search technique known as Tabu search.
One thousandbootstrap replicates were computed using a heuristic search with the optimal criterion set to "parsimony".
For k>4, a different approach using a heuristic search was applied since the exhaustive search is too time-consuming to be practical for our problem.
Tree topologies were evaluated from an initial neighbor joining tree (NJ), using a heuristic search approach that implemented successively branch-swapping methods: (i) tree bisection-reconnection (TBR) branch-swapping, (ii) subtree pruning-regrafting (SPR) and, (iii) nearest-neighbor interchange (NNI).
BANJO, on the other hand, constructs a Bayesian network from discrete data using a heuristic search strategy to explore the space of <img src="http://journals.plos.org/plosone/article/asset?id=info?doi/10.1371/journal.pone.0013580.e420.PNG" class= inline-graphic"/> -node, directed networks without cycles.
PAUP* was used to generate a maximum parsimony phylogeny using a heuristic search algorithm.
This is done using a heuristic search strategy starting from a randomly generated motif.
ME analyses were performed using a heuristic search with a distance optimality criterion [ 46].
For comparison, maximum parsimony trees were also obtained using a heuristic search with TBR branch swapping.
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