Sentence examples for using a genetic mouse from inspiring English sources

"This fine study using a genetic mouse model of Alzheimer's disease coupled to optogenetics offers the tantalising idea that 'tagged' memories can be reactivated by light.

By analysing tendon formation in absence of muscle using a genetic mouse model displaying loss of branchiomeric muscles, we were able to demonstrate that tendons initiate their development independently of muscles but that muscle is required for further tendon development.

Importantly, we show that the combined therapy reduces the size and malignancy of tumours in vivo using a genetic mouse model of breast cancer.

The reason for using a genetic mouse model of NADPH oxidase inhibition is that all pharmacological inhibitors may have nonspecific effects.

107 In vivo studies using a genetic mouse model of chronic, psoriasis-like skin inflammation with double knockout of the JunB and c-Jun alleles 108 was used to investigate the efficacy of G6-31 in reversing clinical and histological skin changes.

Using a genetic mouse model that mirrors partial pharmacological inactivation of p110α, we found that sustained p110α attenuation protects from fat accumulation and deterioration in insulin sensitivity upon ageing and leads to better overall glucose homeostasis compared with control aged mice.

To address this knowledge gap, the present study uses a genetic mouse model with defective hepatic metabolism due to the liver-specific deletion of the cytochrome P450 reductase (cpr) gene to investigate the role of hepatic metabolism in the atropselective disposition of PCB 136 and its metabolites in mice.

We investigated the potential role of nitric oxide (NO) activity in the perivascular niche (PVN) using a genetic engineered mouse model of PDGF-induced gliomas.

This cyclical development of the mammary gland is controlled by various hormonal and genetic signals [reviewed in 1], [ 2] Using a genetic knock-out mouse model, we identified a key role for the epithelial-specific Ets transcription factor, Elf5, in the development of the mammary gland during pregnancy [3].

To investigate this possibility using a genetic approach, APP tg mice were crossed with a line of mice that is heterozygous deficient for endogenous murine Cdk5 gene (CDK5+/−).

In this study, we investigated whether and how PP2Ac α was involved in hepatic fibrosis chronically induced by CCl4 using a genetic PP2Ac α ablation mice model.