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In order to thoroughly evaluate this framework, we implement a prototype – a Semantic Health Service Search Engine, and conduct a series of experiments on the prototype using a functional testing and simulation approach.
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Our mapping results are in agreement with the recent work of Wang and co-authors [28] who identified the SPANX-B promoter region using a functional test.
We first assessed the forelimb muscle strength of the treated and control mice using a functional test of grip force strength (26, 27).
We used a functional test of presynaptic TRPM8 expression by investigating if TRPM8 drives synaptic neurotransmitter release independent of action potential propagation.
Here, we use a functional test (RNA interference, RNAi) to show that Ubx is responsible for the differential growth and enlargement of T3 legs in both Oncopeltus and Acheta.
Gettings and coworkers [ 1] did not use a functional test, and so the reported incidence of 0.9% is the incidence of seroconversion and not necessarily the incidence of HIT, which probably was lower.
We then performed validation testing using a functional MGAM analysis that involved starch ingestion followed by measuring blood glucose and insulin levels as well as hydrogen breath levels.
We also present simulation results using a functional model of mouse metabolism to test its phenotype prediction capabilities.
Endocytosis of dextran is often used as a functional test for the endocytic pathway [ 20- 22].
The authors used a functional enrichment strategy [25] to test the GO terms associated to the parameters measured and to their correlations.
As a second test, we used a functional annotation for E. coli.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com