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Genotype calling would then proceed by counting the number of times each allele is observed and using a fixed cut off value.
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When using a fixed cut-off value for pathological MBF, there is always a probability that patients with MBF close to this cut-off value will be diagnosed differently based on different scans even with the relatively high reproducibility of MBF measurements.
The very different levels of diversity among the different species clusters (Table 2) highlight the difficulties in defining bacterial species using a fixed cut-off value.
Diagnostic algorithms using a fixed cut-off to identify bronchial obstruction are expected to provide higher prevalence estimates in the elderly compared to algorithms using the LLN; in our data, however, this was true for the GOLD but not for the BTS classification.
Pleural fluid ADA decreases with age and therefore increases the number of 'false negative' results for diagnosis of TPE when a fixed cut-off level is used in an older population compared to a younger population.
Moreover, for all the other parameters, instead of considering a fixed cut-off value, we have used a 99%% probability range derived from the available data.
Constraining the parameters to a fixed cut-off value reduces the number of predicted miRNAs.
It has been shown to significantly improve screening performance compared to a fixed cut-off for CA-125 [47].
Measurements take approximately 8 s, and within seconds the system computes both a score (0 10) and a dichotomous output (EIS negative/positive) at a fixed cut-off.
The top discriminators for multi-cancer types were selected by using a fixed cut-off on classification accuracies.
This means that we need a more nuanced approach than using a fixed cut-off of, say, 50% dense.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com