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An investigation using a double knockout mouse model (Abcb1a/1b−/−, Abcc2−/−) may therefore be informative.
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Using a conventional double knockout mouse model for the Gstp1 and Gstp2 genes, we found that the lack of GSTP1/P2 reduced the rate of DNA replication and mitotic index during the first wave of hepatocyte proliferation.
Using a conventional double knockout mouse model for the GstP1 and GstP2 genes, we investigated for the first time the impact of the absence of GSP1/P2 on liver regeneration after two-third PH.
Using a conventional double knockout mouse model for the Gstp1 and p2 genes, we show that GSTP1/P2 is required for the activation of signaling pathways involved in liver regeneration.
A spo0A single gene knockout strain was constructed using a double--crossover genome-editing method.
We tested the predictions using previously published data on a double knockout mutant in an oxygen deprivation network of E.coli.
The optimal control for a double knockout mouse is to use heterozygous mating to produce double WT littermates for comparison, and this is the approach we took for the mice on a pure C57BL/6 background.
To perform a double knockout analysis, we first run standard flux coupling analysis (FCA) using the L4FC routine from [ 18].
A Double Knockout The attack in Egypt relied on a double knockout, the engineers say.
Double KOs impact: Average additional impact of double reaction knockouts, i.e., average number of reactions classes that become blocked by a double knockout { r, s}, but are not blocked by a single knockout of either r or s.
A double knockout was generated with both dystrophin and its homolog utrophin deleted [ 7].
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