Sentence examples for using a dominant interfering from inspiring English sources
The ventral restriction of ectopic spinal 5HT neurons suggested their derivation from presumptive p3[V3] progenitors, and blockade of Nkx2.2 or Foxa2 activity using a dominant interfering derivative of Nkx2.2 (Nkx2.2-VP16 Nkx2.2-VP16oxa2 (Fkh A2 -EnR) [ 5], respectively, prevented RAR403 induction of ectopic 5HT neurons.
We used a dominant interfering mutant Drp1K38A, which prevents shortening of axonal mitochondria by inhibiting mitochondrial fission [ 4, 55, 74].
Role of Akt pathway in the neuroprotective effects of PDGF was further confirmed using a dominant-interfering form of Akt.
We next interfered with grl expression using a dominant negative Suppressor of Hairless DNA binding mutant [Su(H DBM] construct, which interferes with endogenous Su(H) activity by sequestering Notch intracellular domain (notchICD) without DNA binding.
Or the convenience of using a dominant digital service.
We blocked CIL by interfering with Wnt/PCP and Rho signaling using a dominant-negative of Dishevelled (DshDEP+) (Carmona-Fontaine et al., 2008) and the ROCK inhibitor Y-27632 (Carmona-Fontaine et al., 2008; Kadir et al., 2011).
MMTV/ΔNPEA3En mice express a dominant interfering mutant in which the repression domain from the Drosophila melanogaster Engrailed (En) protein is appended to the C-terminal DNA-binding domain of PEA3 [32].
In keratinocytes, MMP-9 production was blocked with an ERK pathway inhibitor (PD98059) or when a dominant interfering JNK mutant was introduced into the cells.
Experimental data suggest that some missense mutations represent dominant interfering mutations [ 1- 5]; however, clinical support for a dominant interfering model is minimal in family studies, suggesting either that the model is flawed or that penetrance of these mutations is very low.
Interference with ERK signalling using a chemical inhibitor or with JNK signalling through use of a dominant-interfering mutant reduces formation of the AP-1 complex and MMP-9 transcription.
Silencing of NUB1 was performed using a small interfering RNA.
