Two-point LOD score was calculated using LIPED where theta is equal to 0 (as a dominant inheritance) with allele frequencies of 0.001 for the disease and translocation breakpoint as published elsewhere (54).
A dominant inheritance model is assumed, and we neglect the probability of an individual exhibiting two rare variants.
This was a family with a dominant inheritance pattern and the APC gene was screened negative.
In the GWAS, Fisher's exact test was applied to three genetic models: an allele frequency model, a dominant inheritance model, and a recessive inheritance model.
This is consistent with a cis-regulating mechanism, showing a dominant inheritance of hypomethylation in genotypes with RJF alleles for FUCA1, and an intermediate, codominant inheritance in PCDHAC1.
Based on the inheritance pattern of DD in the family, the transmission of SNVs among affected individuals was analysed assuming a dominant inheritance pattern with high penetrance.
The data were considered using models assuming dominant inheritance (i.e., women with one or two duplication alleles had the same relative hazard), codominant inheritance (i.e., the relative hazard differed between women with one duplication allele compared with those with two duplication alleles), or recessive inheritance (i.e., only women with two duplication alleles were at increased risk).
Among the 19 800 individuals with available data, we analysed the rs780094 SNP using a co-dominant mode of inheritance as in previous studies.
Since 1975, I have used autosomal-dominant inheritance consistently as one of the requirements for the definition of MODY.
The data were considered by using models assuming either dominant inheritance (that is, women with one or two C alleles had the same relative hazard), co-dominant inheritance (that is, the relative hazard differed between women with one C allele and those with two C alleles) or recessive inheritance (that is, only women with two C alleles were at increased risk).
