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Benefits of using a diverse experimental population are the reduction of erroneous interpretations due to strain-specific effects and the detection of new phenotypes that are not present in standard inbred laboratory strains (Yang et al., 2007, 2011).
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The regression trees were trained using a diverse dataset of 350 mutations with experimental thermodynamic data derived from the ProTherm (69) and SKEMPI (70) databases and used in a blind test in a previous study (43).
To explicitly evaluate the role of structural dynamics in proper biological functioning, we rigorously analyze various biological and functional properties of dfi using a diverse collection of human proteins with known experimental structures.
The authors use a diverse set of experimental tools (photoactivatable sugars, glycosylation inhibitors, lectins and monosaccharides, etc).
Because Pro-Maya uses a diverse set of features, including predictions using two other methods, it also performs slightly better than other methods in the absence of additional experimental data on the query positions.
Use a diverse strategy based on weapons available.
These observations were consistently identified in numerous studies using diverse experimental animal models and varied cell types.
We detected increased levels of SMAD1/5 phosphorylation induced by BMP-2/6, which confirms the recent reports using diverse experimental models, as luciferase reporter assay, osteogenic differentiation-inducing activity and chondrogenic activity [20].
Both internal and induced stresses were examined using diverse experimental systems.
The cataloging involves the identification and curation of genes differentially regulated by RANKL signaling reported in literature as demonstrated using diverse experimental strategies including DNA microarrays, northern blot, serial analysis of gene expression and quantitative RT PCR.
In the past decade several initiatives including the NIH Molecular Libraries Program (Austin et al., 2004) and ChemBank (Seiler et al., 2008) have compiled chemical biology experiments performed by different laboratories using diverse experimental set-ups ranging from cell-free to cell-based and even whole organism-based assays.
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