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A stable preparation of pulmonary hypertension in sheep was developed using a continuous infusion of the vasoconstrictor U46619, a stable endoperoxide thromboxane A2-mimetic.
In initial phase I studies using a continuous infusion dosing schedule in a variety of malignancies, no clinical activity was observed.
Female Yorkshire pigs (32 36 kg) were anesthetized using a continuous infusion of ketamine/xylazine to maintain a surgical plane of anesthesia.
RBF was decreased using a continuous infusion of angiotensin II (AngII, Hypertensin Ciba™, Ciba-Geigy, Basel, Switzerland) with rates set to target a 25% (AngII low) and 50% (AngII high) decrease in RBF.
We have previously validated a method of measuring GFR using a continuous infusion of low dose Iohexol (CILDI) in patients with stable renal function and calculate that variations >10.3% depicts AKI (p = 0.003).
Given that the activity of β-lactams and glycopeptides depends on the time spent with serum drug concentrations greater than the minimum inhibitory concentration of the organism, decreasing the interval between doses or using a continuous infusion may be the best strategy for administering β-lactams and glycopeptides to neutropenic patients.
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Theoretically, stimulation of thyreotrope axis used a continuous infusion of TRH seems to provide clinical benefit.
In this study, the authors used a continuous infusion of either levosimendan or milrinone as inotropic support after corrective congenital cardiac surgery.
We used a continuous infusion of midazolam and sufentanil to achieve a RASS inferior to −4 [17] or a bispectral index under 60 if available [18].
They used a continuous infusion to target serum sodium of 145 to 155 mEq/l [ 10].
Third, we used a continuous infusion of LPS to induce endotoxemia.
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