Sentence examples for using a conditional deletion from inspiring English sources

Using a conditional deletion approach we provide here evidence that Neurod1, a gene regulated by Neurog1 in neurons [2] and by Atoh1 in hair cells [17], suppresses an alternate Atoh1-mediated hair cell fate in cells within the ganglia and aids in differentiation of specific hair cell types in the cochlea.

Using a conditional deletion approach in mice, we find in homozygous Dicer mutants a marked increase of ipsilateral projections, RGC axons extending outside the optic chiasm, the formation of a secondary optic tract and a substantial number of RGC axons projecting aberrantly into the contralateral eye.

To test for a genetic requirement for Notch signaling in CD4+ T differentiation along Th1/Th2 lineages, we used a conditional deletion approach to eliminate all presenilin (PS) activity in CD4+ T cells.

Recently, using a conditional Cre-mediated deletion of the sulfatase-modifying factor 1 gene (Sumf1), which causes the LSD mucosulfatidosis, researchers were able to demonstrate that SUMF1-deficient astrocytes failed to support function and survival of neurons in a wild-type mouse (Di Malta et al., 2012).

Using a conditional knock-out model with inducible deletion of BDNF, we here show that clinical symptoms and structural damage are increased when BDNF is absent during the initiation phase of clinical EAE.

It would be interesting to evaluate separately the specific effect of Cd151 deletion in the stroma (tumor vasculature, immune cells, myoepithelial cells) and the luminal epithelium/tumor cells respectively, using a conditional knock-out model.

Here we investigate the meiotic functions of BAZ1B (WSTF), the only known Tyr142 kinase in somatic cells, using mice possessing a conditional deletion of BAZ1B.

A previous study performed using mice with a conditional deletion of the major TLR signaling adaptor MyD88, which is strictly required for TLR9 signaling in distinct cell types, found that intrinsic MyD88 signaling was required in DCs, but not in B cells, for the enhancing effect of CpG on antibody production in response to immunization with protein antigens.

To evaluate the role of Ihh in OA development, Ihh was specifically deleted in murine cartilage using an Ihh conditional deletion construct (Col2a1-CreER T2 ; Ihhfl/fl).

Georgia Pass (Dundee) described the use of a mouse model with a conditional deletion in the liver cytochrome P450 reductase (HRN) to study cyclophosphamide (CPA) toxicokinetics and therapeutic response.

Mice with a conditional deletion of the β1-integrin gene in early limb development using a mitochondrial peroxiredoxin Prx1-cre transgene showed multiple abnormalities of knee-joint articular cartilage, accompanied by accelerated terminal differentiation.