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All data was analyzed using a computerized program (Statistica V5, Statsoft, Tulsa, OK).
Data were managed using a computerized program using double-check entering and automated codes.
A designated research staff member who is not involved in follow-up data collection or data analysis will carry out randomization using a computerized program.
After physical examination and laboratory tests (hemoglobin and blood count, liver function tests, electrolytes, amylase), and after confirming in utero singleton pregnancies by ultrasound, women were randomized, using a computerized program, to receive Diclegis® (doxylamine succinate 10 mg and pyridoxine hydrochloride 10 mg) or placebo of similar look.
Ten electron micrographs from right atria per animal, chosen by systematic random sampling of squares, were taken at a final magnification of ×15 000 and the numerical density of granules/field, volume density of ANP-granules, mitochondrial and myofibrils and the diameter of all granules present in the field were determined, using a computerized program (Axio Vision, Zeiss).
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Randomization by minimization [ 30] was performed by the Comprehensive Cancer Center Limburg using a computerized randomization program (ALEA).
In Spain and Ragusa Italyy), the questionnaire was administered at a personal interview using a computerized dietary program.
Statistical calculations were performed by using a computerized statistical program (SPSS 13.0; Chicago, IL).
The participants were randomly assigned to either a psychoeducation group (intervention group) or a control group using a computerized randomization program.
Using a computerized randomization program, a co-investigator uninvolved in participants testing or training randomly allocated participants into 1 of 2 groups.
To increase the compliance, the centers in Spain and Ragusa performed a face-to-face dietary interview using a computerized dietary program.
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