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Insulin secretion rate was calculated using a computerised program implementing a regularisation method of deconvolution [ 17] and using a population model of C-peptide kinetics [ 18].
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Toxicokinetics parameters and TK/TD relationships were determined using a computerised curve-fitting program (WinNonlin Pro 3.0; Pharsight Corporation, Mountain View, CA, USA).
Patients' QoL responses were transformed into a QoL profile using a computerised QoL visualisation programme (Middeke et al, 2004).
All measures were calculated using a computerised automated algorithm provided with the device.
Literature was searched using a computerised search of MEDLINE, EMBASE and the Cochrane library.
A study by Matthews et al. [6] investigated this phenomenon further using a computerised simulation model with three-dimensional computed tomography reconstruction of the elbow.
21 gait parameters were measured using a computerised footprint analysis system (DigiGait™).
Prior to and following acquisition of each rCBF map, participants subjectively rated pain intensity and alertness using a computerised VAS.
DigiGait™ Analysis: Footprint analysis was conducted using a computerised digital footprint analysis system (DigiGait™, Mouse Specifics Inc., MA. USA).
These tests consisted of spirometry using a computerised lung analyser (MasterScreen Diffusion, Jaeger GmbH, Höchber, Germany).
Patients will be centrally randomised by the Australian National Health and Medical Research Council NHMRC Clinical Trials Centrere using a computerised interactive voice response system (IVRS).
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