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This sequence is undertaken using a computerised database independent from the clinical team and research staff.
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All practices using a computerised patient database in the three divisions of general practice in one Australian state (Tasmania, population 497 500; figure 1) were invited to participate.
Randomisation was performed 1 1 using a computerised algorithm created by the database manager (JK) with concealed block size, pre-stratified for site of recruitment, initial APACHE II and age (entered in an encrypted screening form in a password protected website); investigators were masked to assignment before, but not after, randomisation.
All measures were calculated using a computerised automated algorithm provided with the device.
Literature was searched using a computerised search of MEDLINE, EMBASE and the Cochrane library.
21 gait parameters were measured using a computerised footprint analysis system (DigiGait™).
Prior to and following acquisition of each rCBF map, participants subjectively rated pain intensity and alertness using a computerised VAS.
DigiGait™ Analysis: Footprint analysis was conducted using a computerised digital footprint analysis system (DigiGait™, Mouse Specifics Inc., MA. USA).
These tests consisted of spirometry using a computerised lung analyser (MasterScreen Diffusion, Jaeger GmbH, Höchber, Germany).
Patients will be centrally randomised by the Australian National Health and Medical Research Council NHMRC Clinical Trials Centrere using a computerised interactive voice response system (IVRS).
Up to seven controls were randomly selected for each case, using a computerised random numbers sequence.
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