Recently, the Baker group designed a high-affinity Zn II -binding site using a computational design approach to incorporate the unnatural amino acid (2,2′-bipyridin-5yl)alanine (Bpy-Ala).
As these target sites are predicted using a computational strategy, we sought to establish whether they gave reasonable correspondence to independently verified target sites and their cognate snoRNAs [ 34- 36].
Using a computational tool, xcons [ 36], such unrelated sites were removed from these CLUSTALW [ 37] alignments to increase probability of site homology.
Using a computational RNA motif model based on common structural elements identified in the HIV-1 and EIAV Rev binding sites, a shared RNA motif was detected within the RREs of HIV-1 and EIAV.
Using a computational platform and your DNA, bioinformatics startup InsideDNA aims to determine the right drug interaction for your body.
Pure geometry and abstraction take over, as he reframes his subjects using a computational method of triangulation.
An alternative approach is to identify structural or sequence similarity with a known binding site, or use a computational tool to predict binding sites on the protein of interest [68].
To address this issue, we used a computational approach to assess whether Fkh-binding sites are enriched in putative enhancers associated with other heart genes (Philippakis et al., 2006; Warner et al., 2008).
To identify the calpain cleavage site of DARPP-32, we used a computational program (gps-ccd) (Liu et al., 2011) that predicts potential cleavage sites.
In this work, we used a computational approach to explore the presence of yet unidentified AtoC binding sites within other parts of the E. coli genome.
