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We then conducted a high-throughput screen using a compound library of 2160 annotated bioactive synthetic compounds and 800 natural products to identify molecules that block normal PLLp migration.
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Fragments were amplified by PCR from the DNA library using a compound SSR primer [ AC 6 AG 5, (TC 6 AC 5] and an adapter primer (5′-CTATAGGGCACGCGTGGT-3′).
Structure based drug design was used to develop a compound library of novel 2,5,6- and 2,5,7-trisubstituted benzimidazoles.
High-throughput screenings based on an enzymatic LDH assay were used to identify PKM2 inhibitor from a compound library of the Food and Drug Administration FDAA) [ 19].
In addition the possible use of MIPs to guide a compound library synthesis towards a desired biological activity is highlighted.
Here, we report that zidovudine resensitizes gemcitabine-resistant pancreatic cancer to gemcitabine as shown by screening a compound library, including clinical medicine, using gemcitabine-resistant cells.
A compound library containing 38 700 compounds was obtained from the Broad Institute of MIT and Harvard compound library and used for the SMM screening and in the hemoglobin oxygen assay.
The compound screening was carried out at the Drug Discovery Unit at the University of Dundee using a kinase-focused compound library from the Scottish Hit Discovery Facility.
Finally, the availability of a rapid method for analyzing the IP6Ks/Vip1s reactions allows for the identification of small molecule inhibitors or enhancers using a small chemical compound library.
To experimentally determine a potential functional epitope or functionally relevant ligand binding site, we used a high-throughput NMR ligand affinity screen using a function-based compound library.
These inhibitors were identified by NMR screening using a library of compounds that consists of one aromatic ring connected to an −NHCOCH3 group by different types of linkers (Ref. 179).
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