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The present experiments were designed to study electrophysiological adaptations in NAc MSNs in the IVSA mouse model of drug-primed reinstatement using a complex paradigm that better replicates the human condition, consisting of repeated cycles of extinction-reinstatement.
Using a complex paradigm of cocaine use consisting of repeated cycles of extinction/reinstatement, a model that closely resembles the human condition, we demonstrate electrophysiological neuroadaptations in NAc MSNs due to either contingent (IVSA in master mice) or non-contingent (yoked mice) administration.
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Consider using a more complex traditional form.
While we applied simple WM maintenance tasks, the above-mentioned studies used more complex paradigms (including more than only WM demands) or composite scores (comprising different task demands and WM domains).
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